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KMID : 0358419800230010053
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Korean Journal of Obstetrics and Gynecology
1980 Volume.23 No. 1 p.53 ~ p.61
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Measurement of Serum hCG β-subunit and α-fetoprotein for Prediction of the Prognosis of Ovarian Cancer
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남궁성은/Namkoong, S.E.
최형락/이준모/김기원/김수평/Choi, H.R./Lee, J.M./Kim, K.W./Kim, S.P.
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Abstract
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It is difficult to predict prognosis and to diagnose remission of ovarian malignancy because these patients take variable clinical course.
Recently attention was focused on carcinoembryonic antigen(CEA) and α-fetoprotein, human placental lactogen, hCG β-subunit and pregnancy specific β1 globulin as specific markers of neoplasms.
Quantitative serial measurement of plasma hCG β-subunit and a-fetoprotein levels as a marker using sensitive double-antibody radioimmunoassays were performed in 27 patients with ovarian malignancy from. 1. Oct., 1977 to 31. Aug., 1979 at the Department of Obstetrics and Gynecology, St. Mary´s Hospital, Catholic Medical School, for prediction of the prognosis after definitive therapy. These patients were studied before and after operation and during chemotherapy. For the purpose of the establishment of the standard level of α-fetoprotein in plasma, 40 non-pregnant healthy women were selected as a control group, randomly.
The results were as follows:
1. Out of 27 patients with ovarian malignancy, the percentages of patients with a positive level of hCG β-subunit and α-fetoprotein in plasma were 40.7 per cent (11 patients) and 14.8 percent (4 patient), respectively.
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